Efficacy and Tolerability of Intravenous Levetiracetam in Childrens

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Efficacy and Tolerability of Intravenous Levetiracetam in Children

Intractable epilepsy in children poses a serious medical challenge. Acute repetitive seizures and status epilepticus leads to frequent emergency room visits and hospital admissions. Delay of treatment may lead to resistance to the first-line anticonvulsant therapies. It has been shown that these children continue to remain intractable even after acute seizure management with approved Food and D...

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Levetiracetam in clinical practice: efficacy and tolerability in epilepsy.

BACKGROUND The aim of this study was to evaluate efficacy and tolerability of levetiracetam (LEV) in patients with different epilepsy syndromes. METHODS We evaluated epileptic patients seen in the previous 18 months, including all patients with present or past exposure to LEV. Tolerability of LEV therapy was evaluated in all patients; efficacy was evaluated only in patients who had received L...

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Efficacy and tolerability of levetiracetam versus phenytoin after supratentorial neurosurgery.

BACKGROUND Antiepileptic drugs are routinely given after craniotomy. Though phenytoin (PHT) is still the most commonly used agent, levetiracetam (LEV) is increasingly administered for this purpose. This retrospective study compared the use of LEV and PHT as monotherapy prophylaxis following supratentorial neurosurgery. METHODS Patients receiving LEV monotherapy after supratentorial craniotomy...

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Efficacy and tolerability of levetiracetam in children aged 10 years and younger: a clinical experience

Levetiracetam is a new anti-epileptic drug that is currently not licensed for use in children. Studies in adults suggest that it may be a useful adjunctive treatment both in partial onset and generalised epilepsy. A retrospective case notes review of 26 children age 10 years and under with refractory epilepsy was undertaken to evaluate the efficacy and safety of the drug. The drug appeared to b...

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Efficacy and tolerability of levetiracetam in patients with therapy-resistant epilepsy and learning disabilities

INTRODUCTION The purpose was to evaluate the effects of levetiracetam (LEV) in routine therapy in learning disabled patients with therapy-resistant epilepsy. METHODS In an open observational add-on study design, 46 patients (residents of the Bethel Epilepsy Centre) with severe therapy-resistant epilepsy and different degrees of learning disabilities, who were treated with LEV between its intr...

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ژورنال

عنوان ژورنال: Frontiers in Neurology

سال: 2013

ISSN: 1664-2295

DOI: 10.3389/fneur.2013.00120